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There is nothing that a UNO deck offers that a regular deck of cards does not unless you are 5 years old and can't quite grasp Crazy Eights. Actually, my 4 year old daughter plays Crazy Eights just fine.
I loved playing Uno as a child, but in college my friend group invented a variation of the rules we call Slow Uno. The basics are that the game is played with 5 Uno decks and each player starts out with 20 cards. All "plus" cards have their value doubled and cards of the same "plus" value can be stacked. If someone plays a card that you have an exact copy of, you can play it out of turn and skip the people in between you and them. Games take a minimum of an hour or so. We've played one game for 5 hours. A great way to bond with your friends.
(+) Plays quickly, approachable for anyone, cheap (-) Too much "take that", skipped turns, the right card to play is always obvious or not important enough to matter, so many other games do similar things better