Specific cards you hate or dread to see come up during a play
In many games out there, there's that one card that you hate or dread seeing because of its devastating effects. It could be a card played by an opponent, a card that comes into your own hand that leaves you with very little choices, or it could be the game itself presenting a brutal outcome (e.g. Pandemic-esque games).
What is that one card and why does it make you groan or fearful after seeing it come up? Pictures for bonus points and please explain in context!